Preparation of antiviral multispray with cationic antimicrobial dialkyldimethyl ammonium salt and sulfobetaine against new coronaviruses (SARS-CoV-2)

The novel sudden acute respiratory syndrome coronavirus 2 is an enveloped virus currently causing severe illness and death worldwide. Common antiseptics such as alcohol have some efficacy in disinfecting everyday surroundings, but development of more effective disinfectants is imperative. A series of studies focusing on cationic antimicrobials resulted in the development of a safe and effective novel coronavirus disinfectant, DEA-171, which provides ≥99.98% inhibition of all novel coronavirus variants within 1 min.

Erratum to: "Efficacy of 265-nm ultraviolet light in inactivating infectious SARS-CoV-2" [Journal of Photochemistry and Photobiology].

[This corrects the article DOI: 10.1016/j.jpap.2021.100050.].

Comprehensive Surveillance of Virus Infection among Captive African Pygmy Hedgehogs in Japan.

African pygmy hedgehogs (Atelerix albiventris) are popular exotic pets in Japan, and their breeding numbers have recently increased. Although various diseases have been reported in hedgehogs, including skin, respiratory, neurological, and neoplastic diseases, most of the causes remain unidentified. In this study, we investigated herpesvirus, adenovirus, and coronavirus infections among 150 African pygmy hedgehogs in Japan and evaluated the correlations between virus infection and diseases. A novel herpesvirus named Atelerix albiventris herpesvirus 1 (AAHeV), and African pygmy hedgehog adenovirus 1 (AhAdV-1) were detected in 14 and 3 oral swab samples, respectively. AAHeV infection may be related to neurological clinical signs. Interestingly, no hedgehog with a neoplastic disorder tested positive for AAHeV. Further research is required to determine the pathogenicity and prevalence of the detected viruses.

Efficacy of 265-nm ultraviolet light in inactivating infectious SARS-CoV-2.

Although, Low-pressure (LP) mercury lamps that emit wavelengths of around 254 nm have been widely applied as ultraviolet (UV) light devices for decontamination of microorganisms, they have raised environmental concerns due to their mercury content. Therefore, UV-LED lamps have high potential for practical use as a replacement for LP mercury lamps. In this study, we evaluated the efficacy of 265-nm UV irradiation in comparison to 254-nm and 280-nm UV irradiation for inactivating infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Irradiation from a 265-nm deep UV light-emitting diode (DUV-LED) lamp efficiently inactivated SARS-CoV-2 at a similar level as a 254-nm UV cold cathode lamp, and at a higher level than a 280-nm DUV-LED lamp.